A Romanian Jew (partly of Armenian descent), Setrakian was held in the Treblinka extermination camp during the Second World War, where he became aware of the Master feeding on the weak and sickly inmates. His first attempt to stop the Master was a failure, leaving him with multiple fractures in his hands that never healed properly. After escaping from the camp, he dedicated his life to hunting down the vampiric scourge for more than six decades. Originally a professor of East European literature and mythology at the University of Vienna, Setrakian was dismissed and forced to go into hiding after refusing to help Eldritch Palmer locate the Master. Wielding an ancient silver sword in his nearly crippled hands, Setrakian is an expert on vampire biology and destruction, and recruits Eph and Nora to his cause. His determination and will are strong, but his weak heart has become an obstacle to his lifelong quest.